9/9/2023 0 Comments Download cholecalciferol![]() ![]() Vitamin D levels decrease with poor dietary intake and low UV-B exposure 5, and inflammatory status (i.e., high interleukin-6 ) also inhibits the synthesis of vitamin D-binding protein (DBP) in the liver. Vitamin D plays a pivotal role in maintaining bone 1, 2 and mineral homeostasis 3, 4. Both thrice-weekly and once-monthly supplementation effectively increases serum 1,25(OH) 2D levels, and hence, reduces active vitamin D drugs.Ĭlinical Trial Registry: This study was registered at and University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR) as NCT02214563 (registration date: ) and UMIN000011786 (registration date: ), respectively (please refer to the links below). ![]() ![]() In conclusion, cholecalciferol supplementation increases serum hepcidin-25 levels in the short term and may increase erythropoietin resistance in the long term among haemodialysis patients. Cholecalciferol also suppressed intact PTH only among patients with severe vitamin D deficiency. Cholecalciferol increased serum 1,25(OH) 2D levels, resulting in a greater proportion of patients who reduced the dose of active vitamin D at Month 6 (31% vs. placebo) group, but were lower at Month 6 with increased erythropoietin resistance. After adjustment for baseline values, serum hepcidin levels were higher at Day 3 in the combined cholecalciferol (vs. Out of 96 participants, 94 were available at Month 3, and 88 completed the 6-month study. ![]() We also examined the effect modifications by selected single nucleotide polymorphisms in vitamin D-related genes. Participants were assigned in a 2:2:1:1 ratio to either (1) thrice-weekly 3,000-IU cholecalciferol, (2) once-monthly cholecalciferol (equivalent to 9,000 IU/week), (3) thrice-weekly placebo, or (4) once-monthly placebo. In this multicentre double-blind randomized clinical trial, we investigated the effects of oral cholecalciferol supplementation on serum hepcidin and parameters related to anaemia and CKD-MBD among haemodialysis patients. ![]()
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